منابع مشابه
Hepatotoxicity of paracetamol and related fatalities.
Paracetamol, also known as acetaminophen, is the most commonly used antipyretic and pain reliever and since 1955 it is available over-the-counter as a single formulation or in combination with other substances and, as indicated by the World Health Organization, it can be used in all the three steps of pain intensity. Paracetamol toxicity is one of the most common causes of poisoning worldwide. ...
متن کاملSilymarin nanoparticle prevents paracetamol-induced hepatotoxicity
Silymarin (Sm) is a polyphenolic component extracted from Silybum marianum. It is an antioxidant, traditionally used as an immunostimulant, hepatoprotectant, and dietary supplement. Relatively recently, Sm has proved to be a valuable chemopreventive and a useful antineoplastic agent. Medical success for Sm is, however, constrained by very low aqueous solubility and associated biopharmaceutical ...
متن کاملGlutathione deficiency in alcoholics: risk factor for paracetamol hepatotoxicity.
Patients chronically abusing ethanol are more susceptible to the hepatotoxic effects of paracetamol. This could be due to an increased activation of the drug to a toxic metabolite or to a decreased capacity to detoxify the toxic metabolite by conjugation with glutathione (GSH). To test these hypotheses paracetamol 2 g was administered to five chronic alcoholics without clinical evidence of alco...
متن کاملPotential protective effect of honey against paracetamol-induced hepatotoxicity.
BACKGROUND Paracetamol overdose causes severe hepatotoxicity that leads to liver failure in both humans and experimental animals. The present study investigates the protective effect of honey against paracetamol-induced hepatotoxicity in Wistar albino rats. We have used silymarin as a standard reference hepatoprotective drug. METHODS Hepatoprotective activity was assessed by measuring biochem...
متن کاملProtective Action of Livol against Paracetamol Induced Hepatotoxicity
Protective action of Livol (a herbal formulation) against paracetamol induced experimental hepatotoxicity was observed in dog. Increased values of serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase, serum total cholesterol and its fractions, globulin, icterus index, prothrombin time and bromosulphalein retention by paracetamol (250 mg/kg, once orally) were decrease...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of the Royal Society of Medicine
سال: 1997
ISSN: 0141-0768,1758-1095
DOI: 10.1177/014107689709000930